International Journal of Head and Neck Pathology

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Malignant extrarenal rhabdoid tumors (ERRTs) are very rare, highly aggressive tumors and are associated with a poor prognosis. They usually occur in young children. Diligent histopathological examination along with the use of judicious immunohistochemistry (IHC) panel is essential to diagnose this rare entity with distinct therapeutic implications. We report a rare case of ERRT with extension up to the skull base involving the right jugular fossa with thrombus in the right internal jugular vein.

Synovial sarcoma (SS) is a malignant soft-tissue tumor of uncertain histogenesis. It is a malignant mesenchymal tumor commonly affecting the extremities. Rarely, it is seen in areas without any relationship to synovial structures. Only 6%–7% of cases have been reported in the head-and-neck region. In head-and-neck region, it usually involves the hypopharynx, parapharyngeal space, and posterior pharyngeal region. A few cases in mandible have been described in literature. Hereby, we report a rare case of monophasic (spindle cell) SS of the mandible in a 17-year-old male with a previous history of tooth extraction along with an unhealed socket.

Spindle epithelial tumor with thymus-like differentiation (SETTLE) is an indolent malignant thyroid tumor seen in children, adolescents, and young adults showing thymic or related branchial pouch differentiation. The tumors are composed of spindle cells along with focal epithelial component and glandular formations. We herein report a case of SETTLE with a follow-up period of 20 years.

The presence of multiple malignancies of different histologies occurring synchronously is very rare and is reported in limited numbers across the literature. We hereby report a case presenting with papillary carcinoma of thyroid gland and mucoepidermoid carcinoma of parotid gland accompanied by regional lymph node metastasis of both the aforementioned malignancies. Recognition of such tumors is quintessential as the management and prognosis vary.

Dentigerous cysts (DCs) and odontomas are lesions of odontogenic origin relatively common in the oral cavity with a rare recurrence after treatment. The purpose of this study is to present a case of association of odontoma with DC in the mandible of a young patient and to describe all cases published in English literature to date. A 16-year-old male patient presented with a well-defined unilocular radiolucent lesion associated with impacted mandibular right canine. Mesially, there was another lesion, mixed with small radiopaque structures, similar to dental structures surrounded by a radiolucent halo. The diagnosis of DC associated with compound odontoma was made. This case report associated with the literature review of other reports highlights that the association of DC with odontoma is rare and further studies are needed to investigate the probable etiology of this association.

Aim: The aim was to study the BRAF status by immunohistochemistry (IHC) in the variants of papillary carcinoma thyroid and compare it with the clinicopathological parameters. Materials and Methods: All the thyroid carcinomas diagnosed during the period of January 2015–June 2018 were reviewed and classified according to the WHO 2017 criteria. The demographic and clinicopathological features were noted. Microarrays were prepared on 27 cases, including classic and variants of papillary thyroid carcinoma (PTC), poorly differentiated thyroid carcinoma (PDTC), and medullary thyroid carcinoma (MTC). IHC was performed with BRAF V600E by automated staining. The BRAF status was correlated with known prognostic markers. Results: There were 23 PTC, 3 PDTC, and one MTC. The PTC included seven classic, three solid, two each of microcarcinoma, infiltrative and encapsulated follicular variant, tall-cell variant (TCV), oncocytic and one each of diffuse sclerosing, nodular fasciitis-like stroma, and Warthin-like variants. BRAF positivity was seen in 44.44%, including 11 PTC and one PDTC. The positivity was 85.71% in classic and 31.25% in variants. The age (>45 vs. <45 years), gender (male vs. female), number of lesions (unifocal vs. multifocal), type of tumor (PTC vs. other tumors), subtype of PTC (classic PTC vs. variants), invasion (capsular vs. lymphovascular), and aggressive features (extrathyroidal extension vs. lymph nodal involvement) between BRAF positive and negative tumors were not statistically significant (Fisher's exact test at P < 0.05). Conclusion: BRAF status did not show correlation with known prognostic variables in classic as well as variants of PTC.

Online since 16^th May 2018.